Volunteers needed for trial

In News by John Geddes

Volunteers are needed for The PROTECT V Trial – Led by Addenbrookes Hospital 

This new exciting trial, led by Dr Rona Smith at Addenbrookes, looks at how patients who are at particularly high risk of Covid-19, might be protected using a variety of drugs. The trial will enrol patients with kidney disease or autoimmune diseases.

This trial is funded by the UK Government and others including KRUK and Addenbrookes Charitable Trust.  

The first drug to be tried out as a prophylactic (preventative) treatment is niclosamide.  This is currently used to treat tapeworm infections, but laboratory experiments with niclosamide have shown it to be effective against the SARS-Cov2 virus, maybe by stopping it multiplying & penetrating into cells. In this trial, the drug will be taken as a nasal spray – to maximise its effect in the nasal tissues, where the virus mainly replicates itself.  

Volunteers will be given either niclosamide or placebo in a “blind” trial.

Here is the list of the centres in PROTECT-V.  If YOU as a patient are keen to join, then YOU should approach your own clinician and ask if their site is active. 

Cambridge University Hospitals NHS Foundation
Bart’s Health NHS Trust, London
East Kent Hospitals University NHS Foundation Trust
Hull University Teaching Hospitals NHS Trust
King’s College Hospital NHS Foundation Trust, London
University Hospitals of Leicester NHS Trust
Sheffield Teaching Hospitals NHS Foundation Trust
Nottingham University Hospitals NHS Trust
Salford Royal NHS Foundation
North Bristol NHS Trust
East and North Hertfordshire NHS Trust
South Tyneside and Sunderland NHS Foundation Trust
Royal Liverpool and Broadgreen University Hospitals NHS Trust
Cardiff & Vale University Health Board
Betsi Cadwaladr University Health Board
Oxford University Hospitals NHS Foundation Trust
The Royal Devon and Exeter NHS Foundation Trust 
Wirral University Teaching Hospital NHS Foundation Trust 
Epsom and St Helier University Hospitals NHS Trust
King’s Lynn
Brighton and Sussex University Hospitals NHS Trust
James Paget Hospital, Great Yarmouth
NHS Tayside
University Hospitals Birmingham NHS Foundation Trust
Royal Berkshire NHS Foundation
Wirral University Teaching Hospital NHS Foundation Trust 
The Royal Wolverhampton NHS Trust
York Teaching Hospital NHS Foundation Trust
Dartford and Gravesham NHS Trust
Dorset County Hospital NHS Foundation Trust
Have had Site initiation call – pending activation
University Hospitals of Derby and Burton NHS Trust
Imperial College Healthcare NHS Trust 
Lantern Centre, Lancashire and South Cumbria
Royal Free NHS Foundation Trust 
Guy’s and St Thomas’ NHS Foundation Trust
Dudley Group NHS Trust
Ayrshire & Arran NHS Trust